Hello readers,

Welcome to 2025. Looking at the big health headlines coming from the NIH, it’s going to be a rough year. So, to maintain your mental health, let’s look elsewhere for the monthly newsletter.

KDIGO published its first guidelines on autosomal dominant polycystic kidney disease. Set aside some time to go through them; the executive summary alone is 20 pages.

Nature Medicine published an interesting trial that mined the VA electronic health record to look for the effects, both good and bad, of GLP-1 RA. The results are super interesting, with strong signals revealing decreased sepsis, pneumonia, and schizophrenia. The negative signals were for musculoskeletal complaints and, interestingly, kidney stones. I have included links to the manuscript, as well as two summaries by Perry Wilson: one on Medscape and the other a Tweetorial on Bluesky.

Speaking of Bluesky and Nature Medicine, Nature did an unscientific poll of their readers and found that 70%(!?) of their audience has moved to Bluesky.

And lastly, as January rolls into February, we’re getting closer to #NephMadness. This year’s contest drops on March 1st. AJKDblog continues the rollout with the annual Meet the Gamemakers post. Link below.

Stay warm, readers.
Spring will soon be here.