Prevention With Joel Kahn, MD

Cardiology

Dr. Kahn is a summa cum laude graduate of the University of Michigan School of Medicine. He practices cardiology in Detroit, is a clinical professor of medicine at Wayne State University School of Medicine, and specializes in vegan nutrition and heart disease reversal.


Heart Disease and Depression: The Inflammation Link

Dear readers,

We have an interesting collection this week. The overlap between coronary heart disease and depression may partially share common pathways of inflammation. The American Heart Association’s Life Essential 8 provides easy targets to hit, and adherence is related to lower calcification of abdominal vasculature.

A plan to ween off of GLP-1 agonists is presented, including the use of Amarasate. I also included more bad news about fish, not only regarding heavy metals but also about microplastics in fish from the United States and Europe. The ketogenic diet was reviewed for heart disease and did not pass the test. CoQ10 augments endothelial function and is a staple in my clinic. A fascinating study on the lifetime risk of atrial fibrillation (rising) points out the risks of stroke and congestive heart failure. Finally, a PET study of the brain shows how exercise reduces stress-related brain signals, particularly in patients with depression.  

Be well,
Joel Kahn, MD, FACC


Articles
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    • Coronary artery disease and major depression may be genetically linked via inflammatory pathways to an increased risk for cardiomyopathy, a degenerative heart muscle disease, researchers have found.

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    • In conclusion, discontinuing semaglutide or tirzepatide therapy for weight reduction poses unique challenges that require careful consideration and management. By comprehensively understanding the potential effects and implementing strategies such as the use of Amarasate® to support patients through this transition, practitioners can optimize patient outcomes and promote long-term success in weight management. 

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    • In a recent study published in the journal Foodsresearchers from Italy, Albania, and Montenegro conducted biomonitoring campaigns on fish and cephalopod species in the Mediterranean Sea to assess contamination levels of cadmium, microplastics, and antibiotics. They found negligible contamination by cadmium and antibiotics but high levels of microplastics in the stomach and gut of Sparus aurata (Gilt-head bream) and Dicentrarchus labrax (European seabass).

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    • Atrial fibrillation (AF) is a common arrhythmia or cardiac rhythm disorder. It is associated with significant mortality risk and also a higher risk of multiple complications. As such, understanding the risk of AF in the population is necessary.

      A new study published online in the BMJ explores the risk of both AF and its complications in a Danish national cohort, beginning from the age of 45 years. The results underline the risk for preventive strategies to reduce the burden of AF on public health. 

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    • New research indicates that physical activity lowers cardiovascular disease risk in part by reducing stress-related signaling in the brain.

      In the study, which was led by investigators at Massachusetts General Hospital (MGH), a founding member of the Mass General Brigham healthcare system and published in the Journal of the American College of Cardiology, people with stress-related conditions such as depression experienced the most cardiovascular benefits from physical activity.