Zanubrutinib Versus Ibrutinib in Relapsed/Refractory Chronic Lymphocytic Leukemia and Small Lymphocytic Lymphoma: Interim Analysis of a Randomized Phase III Trial

Interim analysis of a phase III of zanubrutinib vs ibrutinib shows improved response rates, 12 month PFS and better safety with zanubrutinib. There was decreased major bleeding, cardiac events and AEs leading to discontinuation. Afib was lower at 2.5% vs 10%.

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