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PURPOSE Tumor mutational profiling is increasingly performed in patients with advanced cancer. We determined the extent to which germline mutation profiling guides therapy selection in patients with advanced cancer. METHODS Patients with cancer undergoing tumor genomic profiling were prospectively consented for germline cancer predisposition gene analysis (2015-2019). In patients harboring...

  • In this pan-cancer analysis, men with prostate cancer have the highest rates of pathogenic and actionable germline genetic mutations! This highlights the importance of doing this testing for men with advanced prostate cancer.