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Quick Takes Riociguat is a pulmonary vasodilator that works by directly stimulating soluble guanylate cyclase to produce cyclic guanosine monophosphate (cGMP). Patients with intermediate-risk pulmonary arterial hypertension (PAH) on a phosphodiesterase type 5 (PDE5) inhibitor with or without an endothelin-receptor antagonist (ERA) can achieve significant...