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Blood Cancer Journal

Although methotrexate (MTX) is the most widely used therapy for central nervous system (CNS) prophylaxis in patients with diffuse large B-cell lymphoma (DLBCL), the optimal regimen remains unclear. We examined the efficacy of different prophylactic regimens in 585 patients with newly diagnosed DLBCL and high-risk for CNS relapse, treated with rituximab, cyclophosphamide, doxorubicin, vincristine,...

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    A retrospective review of DLBCL patients treated at MSKCC w/HD MTX ppx failed to show a persistent benefit in decreasing CNS relapse rates. This study adds to the recent data questioning the utility of CNS prophylaxis.