Paper: Replacing the Anthracycline By Gemtuzumab Ozogamicin in Older Patients with De Novo Standard-Risk Acute Myeloid Leukemia Treated Intensively – Results of the Randomized ALFA1401-Mylofrance 4 Study

A RTC which replaced anthracycline in 7+3 with gemtuzumab for older denovo AML patients did not improve outcomes and had increased toxicity. A reminder that ADC / Targeted therapeutics do not always trump conventional chemotherapy.

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