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Oral and Poster Abstracts Oral 905. Outcomes Research-Lymphoid Malignancies: Lymphoma/CLL Real-World Data Clinically Relevant, Clinical Practice (e.g. Guidelines, Health Outcomes and Services, and Survivorship, Value; etc.) Katharine Louise Lewis, BMBS, FRCPath, MRCPath1,2, Lasse H. Jakobsen, MSc, PhD3*, Diego Villa, MD, MPH, FRCPC4, Sabela...

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    retrospective review of 2300 high risk DLBCL patients (CNS IPI 4-6) high-dose methotrexate was not associated with a decreased rate of CNS relapse. CNS relapse rate was ~9% in the total cohort and 5-6% in the cohort of patients who achieved a CR. CNS IPI again predicted patients at high risk for CNS relapse, but unfortunately it does not appear that our current prophylactic approaches are effective.