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7506 Background: Optimal consolidative therapy for primary central nervous system lymphoma (PCNSL) is not defined. Avoidance of whole brain radiation may reduce risk of neurotoxicity. Non-radiation consolidative options include myeloablative chemotherapy with autologous stem cell transplantation (HDT/ASCT) or non-myeloablative chemotherapy. Methods: This is a randomized phase 2, National Clinical...

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    CALGB 51101 – consolidation with autoSCT vs Chemo (AraC+Etop) in PCSNL. Auto superior with mPFS of 6 yrs vs. 2.4yrs. However, more patients went off treatment in the chemo arm prior to randomization due to progression or death. #ASCO2021