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JAMA Network

This nonrandomized phase 2 trial examines remission after combination therapy with ibrutinib and venetoclax in treatment-naive patients with chronic lymphocytic leukemia.

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    Phase II data of frontline Ibrutinib and Venetoclax in 80 higher risk and older CLL patients. Patients had either del(17p) (18%), TP53-mutation (14%), unmutated IGVH, or age>65. 75% achieved MRD negativity in the marrow and estimated 3 year PFS was 93%.