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JAMA Network

This nonrandomized phase 2 trial examines remission after combination therapy with ibrutinib and venetoclax in treatment-naive patients with chronic lymphocytic leukemia.

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    Phase II single arm data of frontline Ibrutinib and venetoclax in older or high risk patients with CLL. Patients had either del(17p), TP53-mutated, del(11q), unmutated IgVH, or age 65 years or older. 75% of patients achieved marrow uMRD as best response. Estimated 3 year PFS was 93%.