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Importance Pediatric SARS-CoV-2 infections and hospitalizations are rising in the US and other countries after the emergence of Omicron variant. However data on disease severity from Omicron compared with Delta in children under 5 in the US is lacking. Objectives To compare severity of clinic outcomes in children under 5 who contracted COVID infection for the first time before and after the...

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    Good US based study on severity of Omicron in U.S. children <5 (by definition unvaccinated) compared to Delta (1st time COVID). Risks for severe clinical outcomes in children with Omicron (ER visits, hospitalizations) much less than Delta (~0.33)