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COVID vaccines are said to "wane" in efficacy but that refers to only one arm of the immune system.

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    Perception in media that COVID-19 vaccines do not work as well for those who are immunocompromised but they are powerful. Study after study (reviewed here0 show strong and redundant immune responses from COVID vaccines in those on immunosuppressants for those with autoimmune diseases or solid organ tumors on chemotherapy. For rare groups where don’t work as well (B cell depleting therapy or solid organ transplant), need Evusheld pre-exposure prophylaxis which lasts 6 months to protect from COVID.