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Key Points. In the population aged ≥80 years, distinct mutational patterns define risk to develop myeloid neoplasms vs inflammatory-associated diseases.In indiv

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    Analysis of 1794 patients >=80yrs old showed that 1/3 had CHIP mutations and it was associated with reduced survival. ~7.5% of the cohort with cytopenias had presumed evidence of myeloid neoplasm. Increased MCV and/or RDW with a MPN related mutation predicted increased risk for developing myeloid neoplasm.