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Heart failure (HF) is responsible for substantial morbidity and mortality and is increasing in prevalence. Although there has been remarkable progress in the treatment of HF with reduced ejection fraction (HFrEF), morbidity and mortality are still substantial. Cardiac contractility modulation (CCM) …

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    Cardiac Contractility Modulation (CCM) enhances myocardial contractility through an increased availability of intracellular Ca, improved myo-filament efficiency and favorable autonomic tone changes