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Asciminib is a novel tyrosine kinase inhibitor (TKI) targeting the myristoyl pocket of BCR-ABL rather than the ATP site, thereby potentially overcoming resistan

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    Asciminib demonstrated superior efficacy (MMR at week 24 was 25.5% v. 13.2%) and tolerability (50.6% vs 60.5% >G3 AEs) compared to bosutinib in patients with chronic phase CML after at least 2 prior TKIs.