Exceptional Response to AKT Inhibition in Patients With Breast Cancer and Germline PTEN Mutations

INTRODUCTIONSection:Cowden syndrome is an autosomal dominant genetic disease with an estimated incidence of one in 200,000. Affected individuals develop multiple systemic hamartomas and have a cumulative lifetime risk of breast cancer of 85%.1 Approximately 80% of patients with Cowden syndrome have a germline inactivating mutation in PTEN (10q23.3).2 PTEN acts as a tumor suppressor gene via…

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