Epigenetic Priming of Bladder Cancer Cells to Enhance CAR T-cell Mediated Cytotoxicity – Expert Commentary

CD19-directed chimeric antigen receptor (CAR) T cells, treat B-cell malignancies, role of DNA methyltransferases inhibitors (DNMTi) and histone deacetylases inhibitors (HDACi) to optimize improving CAR-T cell-mediated tumor-specific cytotoxicity against bladder cancer cells.

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