Elucidating the genetic architecture of DNA methylation to identify promising molecular mechanisms of disease – Scientific Reports

DNA methylation commonly occurs at cytosine-phosphate-guanine sites (CpGs) that can serve as biomarkers for many diseases. We analyzed whole genome sequencing data to identify DNA methylation quantitative trait loci (mQTLs) in 4126 Framingham Heart Study participants. Our mQTL mapping identified 94,362,817 cis-mQTLvariant-CpG pairs (for 210,156 unique autosomal CpGs) at P < 1e−7 and 33,572,145...

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Source: Nature

Categories: Hem/Oncs, Latest Headlines

Tags: cardiovascular, Cholesterol, coronary, covid19, DNA, Framingham, nature

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George Mensah, MD

.@NIH_NHLBI-funded: Jiantao Ma, Dan Levy et al. report putatively causal associations between #DNA methylation biomarkers and #cardiovascular risk factors LDL #cholesterol, #coronary artery disease, and also #COVID19 severity. #Framingham. Read in #Nature https://t.co/SBay6tsusb https://t.co/ww6A23EdNP

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