Background Evidence suggests the role of an inflammatory storm in COVID-19 complications. Colchicine is an orally administered, anti-inflammatory medication beneficial in gout, pericarditis and coronary disease. Methods We performed a randomized, double-blind trial involving non-hospitalized patients with COVID-19 diagnosed by polymerase chain reaction (PCR) testing or clinical criteria. The…
Correspondence to: Ambarish Pandey, MD, MSCS, Assistant Professor of Medicine, Division of Cardiology, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, TX…
This study performs a systematic review to identify which types of system-level initiatives are most effective at improving guideline-directed medical therapy use among patients with…
AbstractAims. Whether or not beta-blocker therapy should be stopped during acutely decompensated heart failure (ADHF) is unsure.Methods and results. In a random
Background—Translation of evidence-based heart failure (HF) therapies to clinical practice is incomplete and may vary internationally. We examined common measures of quality of care in…
Correspondence to: Muthiah Vaduganathan, MD, Brigham and Women’s Hospital Heart and Vascular Center and Harvard Medical School, 75 Francis St, Boston, MA 02115. Email Institute…
BackgroundA run‐in period may increase adherence to intervention and reduce loss to follow‐up. Whether use of a run‐in period affects the magnitude of treatment effects…
This JAMA Guide to Statistics and Methods reviews the use of prerandomization run-in periods to improve treatment adherence and reduce loss to follow-up, and explains…
BackgroundA run‐in period may increase adherence to intervention and reduce loss to follow‐up. Whether use of a run‐in period affects the magnitude of treatment effects…
This prognostic study investigates if models that incorporate routinely collected clinical and laboratory information can predict morbidity and mortality in patients with heart failure and…
Inhibitors of the renin–angiotensin–aldosterone (RAAS) system are cornerstones of the management of patients with heart failure with reduced left ventricular ejection fraction (HFrEF). However, RAAS…
