Plasma triglyceride concentration is easily, inexpensively, and accurately measured, and when elevated is a highly informative disease marker that identifies individuals who frequently have a host of underlying metabolic, inflammatory, and atherogenic risk factors. Although this concept aligns with much that has been discussed regarding the metabolic syndrome, individuals identified with…
Adult-onset type 1 diabetes seems to have weaker familial aggregation and lower heritability than childhood-onset type 1 diabetes. This finding suggests a larger contribution of…
Hyperthyroidism is a common condition with a global prevalence of 0·2–1·3%. When clinical suspicion of hyperthyroidism arises, it should be confirmed by biochemical tests (eg,…
Obesity and overweight has become prevalent in Asian populations. It is estimated that 1 billion people across Asia have a BMI higher than 25 kg/m2,1…
The results of this study support the use of semaglutide 2·4 mg for weight management in people of east Asian ethnicity with overweight or obesity…
This study showed excellent 12-week LDL cholesterol lowering efficacy and good patient tolerance of an oral PCSK9 inhibitor, NNC0835-0434, similar to an injectable drug. However,…
Elevated plasma LDL cholesterol is a major cause of atherosclerotic cardiovascular disease. Accordingly, all clinical practice guidelines advise decreasing LDL cholesterol to very low concentrations…
The prevalence of diabetes and other metabolic NCDs in India is considerably higher than previously estimated. While the diabetes epidemic is stabilising in the more…
Tackling the mechanisms underlying ageing is desirable to help to extend the duration and improve the quality of life. Life extension has been achieved in…
Congenital hypogonadotropic hypogonadism (CHH) is caused by abnormal gonadotropin secretion or action. Although rare, CHH is approximately twice as common in men than in women.1,2…
Applying LCMM to a large cohort of male patients with CHH reversal uncovered two distinct classes of reversal. Genetic investigation combined with careful clinical phenotyping…
