Early-life programming of mesenteric lymph node stromal cell identity by the lymphotoxin pathway regulates adult mucosal immunity

Mucosal immune responses after exposure to pathogens are influenced by multiple factors, including key developmental milestones achieved before birth or during the neonatal period. Li et al. investigated when during mouse immune system development signals initiated by lymphotoxin (LT) expression are needed to enable an effective mucosal IgA antibody response after rotavirus infection of adult…

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