Dara-(C)VRd pre- and post-ASCT for ultra-high risk MM and primary plasma cell leukemia

Patients with newly diagnosed multiple myeloma (NDMM) are currently treated largely using similar regimens regardless of disease status, with ~20–25% of patients experiencing an early relapse. These patients have a median progression-free survival (PFS) of around 24 months with modern induction and transplant pathways and seem to have a reduced response rate to second-line therapies.

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