CRISPR-Based Screen Identifies Host Factors for SARS-CoV-2 Infection
A genome-wide CRISPR knockout screen uncovers a wide array of host genes required for SARS-CoV-2 infection as potential therapeutic targets
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Epigenetic Technologies Find Clinical Applications
Possibilities include the classification of malignancies, the development of anti-obesity drugs, and the reprogramming of cells to reverse age-related diseases.
Artificial Cells Built with Programmable Peptide-DNA Cytoskeletons
Artificial cells built with dynamically reconfigurable peptide-DNA cytoskeletons demonstrate tunable functionality.
Immune Cells Stay on Standby to Defend Immune System
Defense cells are constantly stimulated by healthy tissue to keep them vigilant and ready to respond to pathogens.
Alzheimer’s Disease Neurons Reenter Cell Cycle, Become Senescent
Senescent cells displayed more proinflammatory, metabolically deregulated, and pathology-associated signatures
Immune Cells Stay on Standby to Defend Immune System
Defense cells are constantly stimulated by healthy tissue to keep them vigilant and ready to respond to pathogens.
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Gene therapy has undergone a renaissance in recent years, with several drugs offering beneficial, even life-saving treatments, now approved by the FDA. One example was…
Alzheimer’s Disease Neurons Reenter Cell Cycle, Become Senescent
Senescent cells displayed more proinflammatory, metabolically deregulated, and pathology-associated signatures
Inflammatory Diseases Kindled When HDAC Proteins Act on Th17 Cells
Research shows two class II HDACs regulate cells that produce an important inflammatory cytokine associated with IBD and other disorders.
Streamlining CAR/TCR-T Therapy Manufacturing
Speakers at the recent CAR-TCR Summit Europe in London agreed that despite their efficacy, CAR/TCR-T cell therapy faces challenges that can result in high costs,…
Combatting Muscle Loss in Aging
A new study shows that increased levels of a protein named TP53INP2 in muscle correlate with greater muscular strength and healthier aging in humans.