The coronavirus disease-19 (COVID-19) pandemic underscores the threat posed by newly emerging viruses. Understanding the biology of novel viruses rests in large part on in vitro models that allow viral replication. Human and animal organoids are now proving their value as an experimental virology platform. Hans Clevers discusses the value of organoids as an experimental platform for understanding…
Nature Reviews Endocrinology – Mild autonomous cortisol secretion from benign adrenocortical adenomas (usually diagnosed incidentally) is associated with cardiometabolic risk and other…
Nature Communications – Here, the authors find that a benign polygenic predisposition to lower white blood cell counts is associated with multiple clinical endpoints, suggesting…
Nature Reviews Immunology – This Review discusses the mechanisms by which common alterations of cancer cell metabolism interfere with immune functions to promote immunoevasion and…
Nature Communications – Retinol, a form of vitamin A, plays an essential role in many biological processes throughout the human lifespan. Here the authors identify…
Blood Cancer Journal – Carfilzomib-associated renal toxicity is common and unpredictable: a comprehensive analysis of 114 multiple myeloma patients
Nature Methods – Generating training data for training deep-learning-based tools is time consuming. The DELiVR pipeline facilitates this process as demonstrated in this study on…
Nature Microbiology – IFITM1 can compete with EBV glycoproteins for EphA2 binding and prevent virus entry into epithelial cells, in vitro and in vivo. YTHDF3…
Nature Medicine – Treatment of patients with advanced hepatocellular carcinoma with a personalized DNA vaccine in combination with anti-PD-1 therapy was safe and led to…
Nature Reviews Immunology – This Review discusses the mechanisms by which common alterations of cancer cell metabolism interfere with immune functions to promote immunoevasion and…
Nature Medicine – The posterior hippocampal tail is an important seizure node in humans and may be a promising interventional target in epilepsy.
