COVID-19 poses an extraordinary threat to global public health and an effective vaccine could provide a key means of overcoming this crisis. Human challenge studies involve the intentional infection of research participants and can accelerate or improve vaccine development by rapidly providing estimates of vaccine safety and efficacy. Human challenge studies of low virulence coronaviruses have…
Our detailed breakdown of DALYs associated with a comprehensive list of pathogens on a global, regional, and country level has revealed the magnitude of the…
In 2019, 2540 million (95% uncertainty interval [UI] 2290–2810) disability-adjusted life years (DALYs) were attributed to non-communicable and communicable diseases and injuries globally.1 In The…
Substantial progress has been made in reducing LRI mortality, but the burden remains high, especially in low-income and middle-income countries. During the COVID-19 pandemic, with…
This first-in-human aerosol BCG controlled human infection model was sufficiently well tolerated. Further work will evaluate the utility of this model in assessing vaccine efficacy…
Tuberculosis remains a formidable global health challenge, causing substantial morbidity and mortality due to the limited protection in the lungs provided by the current BCG…
CTH522, adjuvanted with CAF01 or CAF09b, is safe and immunogenic, with 85 μg CTH522-CAF01 inducing robust serum IgG binding titres. Intradermal vaccination conferred systemic IgG…
A vaccine against chlamydia is widely agreed to be an essential public health control measure for both sexually transmitted and ocular infections.1 There have been…
Varicella, also known as chickenpox, is an infectious disease with a characteristic skin rash caused by the Varicella zoster virus. After the initial infection, varicella…
The three dose groups of the candidate v7D vaccine exhibit similar humoral immunogenicity to the vOka vaccine and are well tolerated. These findings encourage further…
Invasive listeriosis is one of the most serious foodborne diseases, and can be categorised into three main clinical forms: septicaemic listeriosis, neurolisteriosis, and pregnancy-associated listeriosis.1…
