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A compact elastocaloric refrigerator
Elastocaloric cooling is regarded as one of the most promising cutting-edge alternatives to conventional vapor compression refrigeration systems. This technology is based on the temperature…
A mechanobiological model of bone metastasis reveals that mechanical stimulation inhibits the pro-osteolytic effects of breast cancer cells
Kumar et al. report the development of advanced in vitro and computational models to help explain the synergistic influence of tumor-bone cell signaling and mechanobiological cues in…
Macrophage memories of early-life injury drive neonatal nociceptive priming
Dourson et al. investigate the effects of injury on peripheral macrophages and how they contribute to neonatal nociceptive priming. Macrophages are essential regulators of this phenomenon…
De novo domestication: what about the weeds?
Most high-yielding crops are susceptible to abiotic and biotic stresses, making them particularly vulnerable to the potential effects of climate change. A possible alternative is…
Altered GM1 catabolism affects NMDAR-mediated Ca2+ signaling at ER-PM junctions and increases synaptic spine formation in a GM1-gangliosidosis model
Weesner et al. find that, in GM1-gangliosidosis mice, neuronal accumulation of GM1 at the ER-PM junctions alters NMDAR-mediated Ca2+ signaling and activates the synaptogenesis pathway via…
Chromophobe renal cell carcinoma
Chromophobe renal cell carcinoma (ChRCC) is the second most common variant histology (non-clear cell) RCC. ChRCC is distinct from clear cell RCC (ccRCC) in terms…
Selective vulnerability of the ventral hippocampus-prelimbic cortex axis parvalbumin interneuron network underlies learning deficits of fragile X mice
Bhandari et al. determine whether the patterns of dysfunctions in Fmr1y/− fragile X model mice result from ubiquitous circuit deficits or might reflect selective vulnerabilities of…
Kinetic cooperativity resolves bidirectional clogging within the nuclear pore complex
As the main gatekeeper of the nucleocytoplasmic transport in eukaryotic cells, the nuclear pore complex (NPC) faces the daunting task of facilitating the bidirectional transport…
Frontiers in plant epigenetics: Cell Press
A collection of papers showcasing the roles of epigenetic modifications in regulating plant development and stress responses.
Lymphoid tissue on the mind
To surveil an organ for pathogens, lymphoid structures need to sample antigens locally. The full set of lymphoid structures involved in surveilling for brain-tropic pathogens…
