Clinical Images: Teenaged boy with lipoma arborescens of the knee and elbow and presumed juvenile idiopathic arthritis
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Evaluation of Progression From Preclinical to Systemic Autoimmune Rheumatic Disease: Novel Use of the European Alliance of Associations for Rheumatology/American College of Rheumatology Systemic Lupus Erythematosus Classification Criteria as an Outcome Measure
Objective Our objective was to evaluate the development of a systemic autoimmune rheumatic disease (SARD) in undifferentiated and asymptomatic individuals with antinuclear antibodies (ANAs). We…
Challenges in Diagnosis and Management of SLE in Africa: An Online Survey
Objective We surveyed African physicians about challenges in diagnosis and management of systemic lupus erythematosus (SLE). Methods We used a cross-sectional, online questionnaire–based survey of…
Single‐Cell Transcriptomics Reveals a Pivotal Role of DOCK2 in Sjögren Disease
Objective Sjögren disease (SjD) is an autoimmune condition characterized by the dysfunction of the salivary and lacrimal glands. The study aimed to decipher the pathogenic…
Therapeutic JAK1 Inhibition Reverses Lupus Nephritis in a Mouse Model and Demonstrates Transcriptional Changes Consistent With Human Disease
Objective Janus kinase family members are essential for signaling by multiple cytokines, including many implicated in systemic lupus erythematosus (SLE) pathogenesis. To test whether inhibition…
B Cell-Depleting Therapy in SLE – The Rheumatologist
“B cells are central orchestraters of autoimmune disease by contributing to autoantibody production, antigen presentation and cytokine production,” says Georg Schett, MD.
A Novel Preclinical Murine Model of Systemic Lupus Erythematosus–Like Cardiovascular Disease
Objective Systemic lupus erythematosus (SLE) affects nine women to every man worldwide, and these patients are at greater risk for cardiovascular disease (CVD) morbidity and…
Persistent Patient‐Level Effect of Guselkumab at Consecutive 8‐Week Dosing Visits and Over Time in Patients With Active Psoriatic Arthritis: Post Hoc Analysis of a 2‐Year, Phase 3, Randomized, Controlled Study
Objective Group-level analyses from the phase 3 DISCOVER-2 trial of guselkumab demonstrated robust and durable improvements across psoriatic arthritis (PsA) domains. To specifically evaluate continu…
Evaluation of Progression From Preclinical to Systemic Autoimmune Rheumatic Disease: Novel Use of the European Alliance of Associations for Rheumatology/American College of Rheumatology Systemic Lupus Erythematosus Classification Criteria as an Outcome Measure
Objective Our objective was to evaluate the development of a systemic autoimmune rheumatic disease (SARD) in undifferentiated and asymptomatic individuals with antinuclear antibodies (ANAs). We…
Association Between 25(OH) Vitamin D Levels and Adverse Pregnancy Outcomes in Systemic Lupus Erythematosus
Objective We evaluated the association of 25(OH) vitamin D levels with adverse pregnancy outcomes in systemic lupus erythematosus (SLE). Methods The Hopkins Lupus Cohort includes…