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Clinical criteria for COVID-19-associated hyperinflammatory syndrome: a cohort study

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The Lancet Rheumatology - We proposed and validated criteria for hyperinflammation in COVID-19. This hyperinflammatory state, cHIS, is commonly associated with progression to mechanical ventilation and death. External validation is needed. The cHIS scale might be helpful in defining target populations for trials and immunomodulatory therapies.

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