The emergence of SARS-CoV in 2003 and SARS-CoV-2 in 2019 highlights the need to develop universal vaccination strategies against the broader Sarbecovirus subgenus. Using chimeric spike designs, we demonstrate protection against challenge from SARS-CoV, SARS-CoV-2, SARS-CoV-2 B.1.351, bat CoV (Bt-CoV) RsSHC014, and a heterologous Bt-CoV WIV-1 in vulnerable aged mice. Chimeric spike mRNAs induced…
Sigal, Pardi, and colleagues show that in mice, CD8+ T-cells do not participate in the pathology of primary SARS-CoV-2 infection and that mRNA-LNP vaccine-induced CD8+…
The hierarchy of immunosuppression predicts SARS-CoV-2 time to clearance and intrahost viral evolution.
Ross River virus is surging in one Australian state, with over 1,500 cases detected since January.
Several Yale experts weigh in on the current dengue fever outbreak in South America and Puerto Rico and discuss implications for the United States.
Oral treatment with obeldesivir completely protects macaques from lethal infection with Sudan ebolavirus
Welcome to the 7th ADSI am pleased to invite you to attend, participate and enjoy the 7th Asia Dengue Summit to be held in Kuala…
View Brett Lindenbach’s obituary, send flowers and sign the guestbook.
The majority of infections have been detected in only five states
Non-antigen vaccines that broadly activate innate immune responses reduce mortality against hospital-acquired bacterial and fungal pathogens.
Nature – The post-COVID travel boom combined with a warm summer have led to dengue outbreaks in Italy and France.
