Cerebellar oscillations driven by synaptic pruning deficits of cerebellar climbing fibers contribute to tremor pathophysiology
Essential tremor (ET) is a neurological disorder characterized by involuntary rhythmic movements of part of the body. The mechanisms underlying ET development are not completely elucidated. Using autoptic brain tissue, mouse models, and EEG analysis in patients, Pan et al. demonstrated that subjects with ET had excessive cerebellar oscillations that correlated with tremor severity. Mechanistic…
