A specific motor decision and its timing can be predicted using information from the cerebellum >10 s before movement, during a cognitive task in larval zebrafish. Decision outcomes and timing can be predicted at the single-trial level, using neuroactivity information from whole-brain Ca2+ imaging, at single-cell resolution.
Functionally compromising variants in RAD51C pre-dispose individuals to breast and ovarian cancer; identifying these variants is critically important for the clinical management of patients and…
In-cell cryo-electron tomography has uncovered the Ebola virus nucleocapsid assembly and condensation processes. The resulting 9 Å map of fully assembled nucleocapsids within the viral replication…
The biosynthetic pathways in plants that yield important and clinically relevant toxins are complicated and difficult to elucidate. Through combined metabolomics, the biosynthetic pathways of…
TEX264, a conserved and cancer-relevant autophagy receptor, orchestrates selective autophagy of DNA lesions induced by topoisomerase 1 cleavage complexes to ensure genome stability and cell…
Functional genomic analyses of multiple brain regions across three major neurodegenerative disorders involving tau pathology, AD, bvFTD, and PSP, at the single-cell level enables the…
An mRNA vaccine was designed against Orthopoxviruses (including mpox and smallpox) and compared with current standard of care modified vaccinia Ankara (MVA) vaccines in a…
Despite extensive studies on nutrition and the abiotic components of food, the food microbiome remains largely uncharacterized. In this study, a systematic metagenomic sequencing of…
In this issue of Cell, Penzes et al. describe the use of cryo-EM to identify the cause of a mysterious disease affecting farmed superworms across the…
Long COVID is a chronic and often disabling illness with long-term consequences. Although progress has been made in the clinical characterization of long COVID, no…
The non-structural protein NSs of Rift Valley fever virus forms a filamentous E3 ligase to trigger efficient degradation of the cellular TFIIH complex, leading to…
