Zhang et al. show that selective CDK7 inhibition with YKL-5-124 disrupts the cell cycle and causes replicative stress, eliciting an inflammatory response. YKL-5-124 in combination with anti-PD-1 therapy reduces tumor growth and increases survival in mouse models of small cell lung cancer.
Stratification strategies for chemotherapy plus anti-PD-1 treatment in advanced NSCLC are critically demanded. Xu et al. develop an integrated ctDNA-based stratification strategy based on a phase…
Liu et al. show that interneuron lineage progenitor-like states, emulating spatial niches of human brain development, present a distinct vulnerability and highlight CDK6 as a promising…
Precision oncology endeavors to tailor therapies based on individual patient and tumor characteristics. This rapidly evolving field has transformed cancer treatment across all age groups.…
Precision oncology endeavors to tailor therapies based on individual patient and tumor characteristics. This rapidly evolving field has transformed cancer treatment across all age groups.…
Neoadjuvant chemoradiotherapy has been a mainstay of the treatment of locally advanced rectal cancer. Programmed cell death protein 1 (PD-1) blockade therapy has demonstrated efficacy…
In this issue of Cancer Cell, McIntyre et al. show that specific mutations in the KRAS proto-oncogene shape clinical progression of pancreatic ductal adenocarcinoma (PDAC). Importantly,…
Over the last 10 years, numerous studies have profiled human tumors by single-cell RNA-seq. In this perspective, Tirosh and Suva describe the cell states most…
Over the last 10 years, numerous studies have profiled human tumors by single-cell RNA-seq. In this perspective, Tirosh and Suva describe the cell states most…
Wang et al. analyze longitudinal blood from melanoma patients on checkpoint blockade using paired single-cell RNA and TCR sequencing and uncover waves of clonal responses that…
McIntyre et al. demonstrate in an analysis of 1,360 patients the key features of early-stage pancreatic ductal adenocarcinoma (PDAC), including an enrichment of KRASG12R disease that…
