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    This randomized clinical trial examines changes in body composition components with use of a Mediterranean diet plus physical activity compared with ad libitum use of the Mediterranean diet in adults with overweight and obesity after 3 years.

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    • This interim subgroup analysis the PREDIMED-Plus RCT showed that an intervention with energy-reduced MedDiet and physical activity reduced total and visceral fat and attenuated age-related losses of lean mass in older adults. https://t.co/BNJnyol4Ew

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    Background Despite the improvements in treatment over the last decades, periodontal disease (PD) affects millions of people around the world and the only treatment available is based on controlling microbial load. Diabetes is known to increase the risk of PD establishment and progression, and recently, glucose metabolism modulation by pharmaceutical or dietarian means has been emphasised as a significant modulator of non-communicable disease development. Methods The impact of pharmaceutically controlling glucose metabolism in non-diabetic animals and humans (REBEC, UTN code: U1111-1276-1942) was investigated by repurposing Metformin, as a mean to manage periodontal disease and its associated systemic risk factors. Results We found that glucose metabolism control via use of Metformin aimed at PD management resulted in significant prevention of bone loss during induced periodontal disease and age-related bone loss in vivo. Metformin also influenced the bacterial species present in the or

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    • A study published in the Journal of Translational Medicine demonstrates that glucose metabolism control for periodontal disease management via Metformin, results in significant prevention of induced and age-related bone loss. https://t.co/6NXEKK6jtg