Bridging the Gap Between Epigenetic and Genetic in PAH – American College of Cardiology
Quick Takes Tet methylcytosine dioxygenase 2 (TET2), an epigenetic regulator that demethylates cytosine, is mutated in both idiopathic pulmonary arterial hypertension (PAH) and associated PAH. TET2 expression is ubiquitously decreased in peripheral blood cells of paitents with both idiopathic and associated PAH. TET2 depletion creates a…