Base editor treats progeria in mice
Single dose of adenine base editor shows promise in treating ageing-related syndrome.
Single dose of adenine base editor shows promise in treating ageing-related syndrome.
Nature Communications – The nuclear localization of metabolic enzymes is fascinating and in most cases remains a mystery. Here, Pardo Lorente and colleagues show that…
Nature Biotechnology – Thousands of rare oncogene variants are evaluated using multimodal gene editing screens.
Nature Reviews Endocrinology – Nutritional imbalances (such as overnutrition in obesity) alter many properties of the neurovascular system, including neurovascular coupling and blood–brain…
Nature Reviews Endocrinology – Phaeochromocytomas and paragangliomas (PPGL) are rare endocrine tumours that can affect paediatric patients as well as adults. In this first international…
Nature Biotechnology – Thousands of rare oncogene variants are evaluated using multimodal gene editing screens.
Nature Aging – Therriault et al. provide a framework for the individual-level interpretation of plasma biomarkers by determining their positive and negative predictive values for…
Nature Communications – Glucocorticoid resistance is partly due to epigenetic alterations, but the regulatory mechanisms driving these remain poorly understood. Here, a link between the…
Nature Communications – Metagenomic next-generation sequencing has the potential to support diagnosis of unknown infections as it can identify all potential pathogens without requiring a…
Nature Medicine – Next-generation metagenomic testing increases the accuracy and sensitivity of the etiology of central nervous system infections in hospitalized patients.
Nature – The code underlying the Nobel-prize-winning tool for modelling protein structures can now be downloaded by academics.