Assessment of the long-term effectiveness of disease-modifying therapies in multiple sclerosis is plagued by methodological issues, but statistical methods continue to evolve. Use of a novel approach has highlighted the importance of accounting for cumulative exposure to disease-modifying therapies when assessing the long-term effects of treatment on disability accumulation.
RAB32 Ser71Arg is a novel genetic risk factor for Parkinson’s disease, with reduced penetrance. The variant was found in individuals with Parkinson’s disease from multiple…
Background: This study investigates clinical and biomarker differences between standard interval dosing (SID) and extended interval dosing (EID) of ocrelizumab …
Huang et al. examine how a person’s genetic make-up affects their immune response to Epstein-Barr virus and how this relationship affects risk for multiple
Sánchez-Juan et al. reveal an association between serum GFAP levels and post-mortem tau pathology in patients with dementia, independent of amyloid deposit
Annals of Neurology is a leading neurology journal from the American Neurological Association focusing on diseases of the human nervous system.
BACKGROUND Alzheimer’s disease (AD) prevalence increases with age, yet a small fraction of the population reaches ages > 100 years without cognitive decline. We studied…
INTRODUCTION In trials of amyloid-lowering drugs for Alzheimer’s disease (AD), differential eligibility may contribute to under-inclusion of racial and ethnic underrepresented groups. We examined pl…
This Series highlights the importance of efforts to improve diversity, equity and inclusion (DEI) in the neurology community and in neurological care to …
Nature Medicine – An exploratory analysis of the 1-year clinical trial PASADENA in individuals with early-stage Parkinson’s disease suggests that prasinezumab might reduce motor signs…
Nature Medicine – An exploratory analysis of the 1-year clinical trial PASADENA in individuals with early-stage Parkinson’s disease suggests that prasinezumab might reduce motor signs…
