Angiotensin-converting enzyme 2 expression is not induced by the renin–angiotensin system in the lung

Coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has developed into a pandemic with significant morbidity and mortality. SARS-CoV-2 has been reported to invade lung epithelium via the angiotensin-converting enzyme 2 (ACE2) receptor using its glycosylated cell surface spike protein [1]. ACE2 expression in the heart and kidney is regulated…

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