COVID-19 is becoming a leading cause of mortality throughout the world, and few effective therapies are currently available. Angiotensin converting enzyme 2 (ACE2) is essential to COVID-19 pathogenesis, as the binding of SARS-CoV-2 spike protein (S protein) is required for viral entry and development of COVID-19. ACE2 regulates the protective arm of the renin-angiotensin-aldosterone system (RAAS)…
Chemistry is indispensable for the elaboration of all products used in everyday life, such as manufactured goods, materials, fuels and devices for energy, construction, transportation,…
Patterns is a new gold open access journal publishing transformative, peer-reviewed research across the spectrum of research disciplines including computational, physical, life, and social sciences,…
This work demonstrates a fully stretchable and integrated power source, consisting of a triboelectric nanogenerator (TENG), a polymeric four-transistor rectifier, and a supercapacitor, designed to…
Chronic stress is associated with increased risk of metastasis and poor survival in cancer patients, yet the reasons are unclear. In this paper, Dr. Mikala…
Living cells embedded in an extracellular matrix sense and respond to mechanical stimuli in their environment. We have developed a method for magnetic matrix actuation…
The ubiquity of bacteriophages (phages) and the major evolutionary and ecological impacts they can have on their microbial hosts has resulted in phages often cited…
N6-Methyladenosine (m6A) modification regulates gene expression at transcriptional and post-transcriptional levels. In plants, it plays vital roles in development, biotic and abiotic stress responses, and…
We introduce a highly realistic model of a beating heart that accurately replicates mitral valve function in both health and disease. Our simulator integrates real…
This study sequenced 110 genomes from diverse macroalgae to identify key genetic determinants underlying the independent evolution of multicellularity in three major lineages: Rhodophyta, Chlorophyta,…
We show that illumination can initiate the motion of particles embedded in rotaxane-doped liquid crystals. The position of the macrocycle in the rotaxane molecular shuttle…
