Objective To test the hypothesis that absence seizures can evolve to generalized tonic-clonic seizures, we documented electroclinical features of this novel seizure type. Methods In 4 large video-EEG databases, we identified recordings of seizures starting with impaired awareness that, without returning to baseline interictal state, evolved to generalized tonic-clonic seizures. We extracted the…
Background and ObjectivesMounting evidence points to a strong connection between cardiovascular risk during middle age and brain health later in life. The American Heart Association’s…
Given the relatively low incidence, high prehospital death rate, substantial geographical differences, and complex disease origin (combination of genetic and environmental risk factors), epidemiologic research…
The December 2024 replay wraps up the year with five previously posted episodes on autoimmune neurology. The episode begins with Drs. Michael R. Wilson and…
A 16-year-old boy presented with generalized tonic-clonic seizures, irritability, and forgetfulness. Neurologic examination revealed cognitive impairment and ataxic gait. Brain MRI revealed multiple hyperintense nodular…
Autoimmune nodopathy is a rare, debilitating, demyelinating polyneuropathy triggered by autoantibodies targeting peripheral nerve nodal and paranodal proteins including neurofascin-155 (NF155), contactin-1 (CNTN1), contactin-associated protein-1…
Background and ObjectivesRecent technological advances have enabled visualizing in vivo a subset of chronic active brain lesions in persons with multiple sclerosis (pwMS), referred to…
ObjectivesTo describe a novel subtype of autoimmune myopathy, immune-mediated megaconial myopathy (IMMM), myopathologically characterized by giant mitochondria (megaconia).MethodsIn this case series, we reviewed the Mayo…
ObjectivesTo describe a novel subtype of autoimmune myopathy, immune-mediated megaconial myopathy (IMMM), myopathologically characterized by giant mitochondria (megaconia).MethodsIn this case series, we reviewed the Mayo…
The artery of Percheron (AOP) is a rare thalamic blood supply with four distinct variants, first described in 1973 by French neurologist G é rard…
Background and ObjectivesMultiple-choice questions (MCQs) are a pervasive assessment method in medicine. Learners are adept at test score optimization strategies, and performance may belie erroneous…
